Jishnu Das
Principal Investigator
Jishnu completed an undergrad degree in Bioengineering at the Indian Institute of Technology Kanpur followed by graduate studies in Computational Biology at Cornell University. After a short postdoc at the Ragon Institute of MGH, MIT & Harvard/MIT, Jishnu started his Systems Immunology lab. His most important role is that of a "translator" of jargon across disciplines (comp bio, basic and translational clinical immunology); this helps bridge the interdisciplinary expertise in the lab.
Changelog (2)
January, 2026
January, 2026
Jishnu gets promoted to Associate Professor in the Department of Immunology!January, 2020
January, 2020
The lab is now open! We look forward to exciting science in the future!Publications (108)
Comprehensive Atomic-Scale 3D Viral-Host Protein Interactomes Dissect Key Mechanisms of Viral Pathogenesis
10/07/2026 - Nature Methods
Li L*, Guha Roy P*, Liu Y, Zhang Z, [...], Gokhale N, Schang L^, Das J^, Yu H^
SIV infection disrupts the spatial cellular and communication networks of pulmonary granulomas during SIV/MTB co-infection
09/24/2026 - JCI Insight
Medrano J, Sunny P, Diedrich C, Maiello P, [...], Mattila J, Das J, Ambrose Z, Lin P
Cutaneous nonpeptidergic neurons sense extracellular ATP to augment barrier repair and C. albicans host defense
08/20/2026 - Cell Press Blue
Edwards T, Chen C, Cattley R, Mehta I, [...], Davis B, Hawse W, Das J, Kaplan D
Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning
07/30/2026 - JCI Insight
Kale S, Vincent A, Ross M, Mehta I, [...], Wenzel S, Das J^, Ray A^, Gauthier M^
A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation
07/22/2026 - Nature Communications
Omelchenko A, Rahman S, Wang A, Tabib T, [...], Pillai S, Elsner R^, Mahajan V^, Das J^
Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo
07/06/2026 - Journal of Biological Chemistry
Natarajan N, Ahmed T, Govindaswamy B, Manickam D, Das J, Islam K, Dutta P
IL4Ra blockade inhibits proliferation of malignant lymphocytes and the immunosuppressive tumor microenvironment of mycosis fungoides.
06/25/2026 - Journal for ImmunoTherapy of Cancer
Gaydosik AM, Wang A, Das J, Lapolla B, Akilov OE, Geskin LJ, Fuschiotti P
Comparative transcriptional profiling of key macrophage and fibroblast subpopulations in rheumatoid arthritis-associated lung disease
06/22/2026 - Arthritis and Rheumatology
Tabib T, Ezenwa O, Sciurba J, Valenzi EB, [...], Cody B, Das J, Lafyatis R, Ascherman DP
BPTF is essential for vaccine-induced germinal center B cell responses
06/07/2026 - Journal of Immunology
Sturtz A, Evavold B, Heidari Rarani Z, Alsoussi W, [...], Das J, Turner J, Pardi N, Ellebedy A
Immune BioGraphy: A tale of graphical approaches in systems and virtual immunology
06/05/2026 - Cell Systems
Keshari S*, Chakraborty T*, Das J^
Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future
06/01/2026 - Investigative Ophthalmology and Visual Science
Matynia A, Meng I, Davis B, Pflugfelder S, [...], Jacobs D, Aicher S, St Leger A, Saban D
Postprandial changes to systemic lipid metabolism imprint durable enhancements to T cell immunity
04/29/2026 - Nature
Kumar A, Rivadeneira D, Mehta I, Xie B, [...], Das J, Hawse W, Kohan A, Delgoffe G
RepurNet: A network medicine framework for systematic drug repurposing and disease vulnerability discovery
04/27/2026 - iScience
Pentaparthi S, Zou R, Chhibbar P, Shrawat A, [...], Das J, Sahni N, Wu E, Yi S
FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling
04/22/2026 - JCI Insight
Behera R, Zhou Y, Gerges P, Fan J, [...], Chan S, Singh H, Valenzi E, Lafyatis R
Blimp1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition
04/20/2026 - Nature Immunology
Manakkat Vijay G, Ramaswami B, Gierlack S, Pease N, [...], Salomonis N, Das J, Rothstein D, Singh H
Identifying systemic lupus erythematosus from serum proteomic profiles using machine learning and genetic risk stratification
03/26/2026 - Arthritis & Rheumatology
Hocaolu M, Das J, Sawalha A
Multi-modal integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes
02/11/2026 - Arthritis & Rheumatology
Rahimikollu J*, Guha Roy P*, Kishore A, Lee D, [...], Ascherman D, Schwartz D, Moreland L, Das J^
The production of the chemokine, CCL2, by corneal sensory neurons initiates anti-viral immunity at the cornea and trigeminal ganglion
01/27/2026 - Cell Reports
Yun H, Moghbeli K, Gerges P, Cisney R, [...], Kaplan D, Singh H, Davis B, St. Leger A
Altered AP-1, RUNX and EGR chromatin dynamics drive fibrotic lung disease
12/31/2025 - Annals of the Rheumatic Diseases
Valenzi E, Jia M, Gerges P, Fan J, [...], Das J, Benos P, Singh H, Lafyatis R
Sucralose consumption ablates cancer immunotherapy response through microbiome disruption
07/30/2025 - Cancer Discovery
Morder M, Nguyen M, Wilfahrt D, Dahmani Z, [...], Delgoffe G, Das J, Davar D, Overacre-Delgoffe A
Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life
07/30/2025 - Nature
Ardeshir A, O-Hagan D, Mehta I, Shandilya S, [...], Farzan M, Desrosiers R, Das J, Martins M
Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions
07/28/2025 - Nature Methods
Siwek J*, Omelchenko A*, Chhibbar P*, Arshad S, [...], Shlomchik M, Koes D, Joglekar A^, Das J^
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
07/09/2025 - Cell
Phelps C, Willis N, Duan T, Lee A, [...], Das J, Pierre J, Trincheiri G, Meisel M
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males
05/28/2025 - Science Translational Medicine
Sun X, Abdelhamid SS, Secunda Z, Voinchet R, [...], Neal MD, Kar UK, Sperry JL, Billiar TR
Unique and shared transcriptomic signatures underlying localized scleroderma pathogenesis identified using interpretable machine learning
04/08/2025 - JCI Insight
Rosen AB*, Sanyal A*, Werner THG, Berkowitz JS, [...], Lafyatis R, Jacobe H, Das J^, Torok KS^
Machine learning approaches enable the discovery of therapeutics across domains
04/03/2025 - Molecular Therapy
Chhibbar P^, Das J^
Immuno-oncology recapitulates ontogeny- Modern cell and gene therapy for cancer
03/28/2025 - Molecular Therapy
Carleton N, Rosen AB, Das J, Lotze MT
High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation
03/18/2025 - Cell Reports Medicine
Moheimani H, Sun X, Ozel M, Darby JL, [...], Barrett CD, Das J, Sperry JL, Billiar TR
Opportunities in AI/ML to endotype asthma and other eosinophilic diseases
02/14/2025 - Journal of Allergy and Clinical Immunology
Ray A^, Das J^, Khoury P^
Dysfunctional KLRB1+CD8+ T-cell responses are generated in chronically inflamed systemic sclerosis skin
02/01/2025 - Annals of the Rheumatic Diseases
Gaydosik AM, Tabib T, Das J, Larregina A, Lafyatis R, Fuschiotti P
The survival of B cells is compromised in kidney disease
12/30/2024 - Nature Communications
Peroumal D, Jawale CV, Choi W, Rahimi H, [...], Nolin TD, Das J, Alcorn JF, Biswas PS
Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation
12/11/2024 - Science Translational Medicine
Zhang YR, Keshari S, Kurihara K, Liu J, [...], Falo LD Jr, Das J, Sumpter TL, Kaplan DH
Uncovering cell-type-specific immunomodulatory variants and molecular phenotypes in COVID-19 using structurally resolved protein networks
11/24/2024 - Cell Reports
Chhibbar P*, Roy P*, Harioudh M*, McGrail D, [...], Yi SS, Sahni N, Sarkar S, Das J^
Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD
11/08/2024 - JCI Insight
Sui J*, Xiao H*, Mbaekwe U, Ting NC, [...], Zhang Y, Sciurba FC, Das J^, Kliment C^
Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen
10/14/2024 - Nature Immunology
He K, Xiao H, MacDonald WA, Mehta I, [...], Weaver CT, Lambrecht BN, Das J, Poholek AC
Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis
09/11/2024 - Science Translational Medicine
Saha A*, Chakraborty T*, Rahimikollu J, Xiao H, [...], A OFraga L, Fairley JK^, Das J^, Sarkar A^
Deciphering the impact of genomic variation on function
09/04/2024 - Nature
IGVF Consortium
Tim-3 Is Required for Regulatory T Cell?Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection
08/30/2024 - Journal of Immunology
Nieves-Rosado H, Banerjee H, Gocher-Demske A, Manandhar P, [...], Das J, Vignali D, Delgoffe G, Kane L
Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics
08/12/2024 - PLoS Computational Biology
Chavez R, Fili M, Han C, Rahman S, [...], Darbro B, Das J, Brown G, Haim H
High-dimensional profiling of immune responses to kidney transplant reveals heterogeneous T helper 1 and B cell effectors associated with rejection
08/12/2024 - American Journal of Transplantation
Louis K, Tabib T, Macedo C, Wang J, [...], Das J, Singh H, Lefaucheur C, Metes D
Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis
08/11/2024 - Nature Communications
Natarajan N, Florentin J, Johny E, Xiao H, [...], Tavakoli S, Shiva S, Das J, Dutta P
The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis
07/12/2024 - Journal of Experimental Medicine
Li Y, Vyas S, Mehta I, Asada N, [...], Biswas P, Savan R, Das J, Gaffen S
Temporal dynamics and genomic programming of plasma cell fates
06/19/2024 - Nature Immunology
Vijay G, Zhou M, Thakkar K, Rothrauff A, [...], Borghesi L, Salomonis N, Xu H, Singh H
Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery -Impact of Aging and Comparison with Traumatic Injury Response
05/12/2024 - Journal of the American College of Surgeons
Bonaroti J, Ozel M, Chen T, Darby J, [...], Kar U Zuckerbraun B, Das J, Okonkwo D, Billiar T
Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells
03/25/2024 - Journal of Immunology
Grebinoski S, Pieklo G, Zhang Q, Visperas A, [...], Herrada A, Das J, Workman C, Vignali D
Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data
03/25/2024 - Nature Computational Science
Osorio D, Capasso A, Eckhardt S, Giri U, [...], Das J, Sahni N, Yi S, Kuijjer M
SLIDE- Significant Latent factor Interaction Discovery and Exploration across biological domains
02/19/2024 - Nature Methods
Rahimikollu J*, Xiao H*, Rosengart A, Rosen A, [...], Poholek A^, Joglekar A^, Lafyatis R^, Das J^
PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
12/19/2023 - Cell Reports Medicine
Li H, Dobrolecki L, Sallas C, Zhang X, [...], Yi S, Bedford M, McGrail D, Sahni N
SARS-CoV-2 mRNA vaccines induce greater complement activation and decreased viremia and Nef antibodies in men with HIV-1
11/30/2023 - The Journal of Infectious Diseases
Tuttle D, Castanha P, Nasser A, Wilkins M, [...], Mailliard R, Sluis-Cremer N, Rinaldo C, Marques E
From bench to bedside via bytes- multi-omic immunoprofiling and integration using machine learning and network approaches
11/09/2023 - Human Vaccines & Immunotherapeutics
Xiao H*, Rosen A*, Chhibbar P*, Moise L, Das J^
The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells
08/08/2023 - Immunity
Sanchez L, Siller M, Zeng Y, Brigleb P, [...], Das J, Dermody T, Verdu E, Hinterleitner R
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A
07/18/2023 - Journal of Experimental Medicine
Johnson-Hence C, Gopalakrishna K, Bodkin D, Coffey K, [...], Sosa Y, Tometich J, Das J, Hand T
High dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma
06/04/2023 - Journal of Trauma and Acute Care Surgery
Li SR, Moheimani H, Herzig B, Kail M, [...], Das J, Kar U, Sperry J, Billiar TR
Cell Type-Specific Biomarkers of Systemic Sclerosis Disease Severity Capture Cell-Intrinsic and Cell-Extrinsic Circuits
04/25/2023 - Arthritis and Rheumatology
Berkowitz J, Tabib T, Xiao H, Sadej GM, [...], Khanna D, Fuschiotti P, Lafyatis R^, Das J^
Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates
04/25/2023 - Cell Reports Medicine
Gunn B, McNamara R, Wood L, Taylor S, [...], Nilsson A, Shurtleff A, Dubey S, Eichberg M
Landscape of microRNA regulatory network architecture and functional rerouting in cancer
01/04/2023 - Cancer Research
Hua X, Li Y, Pentaparthi SR, McGrail DJ, [...], Wu E, Huang JH, Sahni N, Yi SS
Lipidomic signatures align with inflammatory patterns and outcomes in critical illness
11/10/2022 - Nature Communications
Wu J, Cyr A, Danielle G, Lovelace T, [...], Stensballe J, Namas R, Vodovotz Y, Sperry J
Determining asthma endotypes and outcomes- Complementing existing clinical practice with modern machine learning
11/10/2022 - Cell Reports Medicine
Ray A^, Das J^, Wenzel S^
High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI
10/14/2022 - Annals of Surgery
Wu J, Moheimani H, Li S, Kar U, [...], Neal M, Das J^, Sperry J^, Billiar T^
Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients
08/23/2022 - Metabolites
Abdelhamid S, Scioscia J, Vodovotz Y, Wu J, [...], Neal MD, Sperry J, Das J^, Billiar TR^
A Supervised Take on Dimensionality Reduction via Hybrid Subset Selection
08/12/2022 - Patterns
Rahimikollu J*, Das J^
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
07/26/2022 - Nature Immunology
Grebinoski S, Zhang Q, Cillo AR, Manne S, [...], Wherry EJ, Das J, Workman CJ, Vignali DAA^
Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19
06/28/2022 - Cell Reports
Peddireddy SP*, Rahman S*, Cillo AR, Vijay GM, [...], Morris A, Singh H^, Sarkar A^, Das J^
Essential Regression- A generalizable framework for inferring causal latent factors from multi-omic datasets
05/13/2022 - Patterns
Bing X*, Lovelace T*, Bunea F, Wegkamp M, [...], Kasturi S, Singh H^, Benos P^, Das J^
A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation
04/19/2022 - Cell Reports Medicine
Ningappa M*, Rahman S*, Higgs B.W, Ashokkumar C, Sahni N, Sindhi R^, Das J^
Functional reprogramming of monocytes in acute and convalescent severe COVID-19 patients
04/05/2022 - JCI Insight
Brauns E, Azouz A, Grimaldi D, Xiao H, [...], Dauby N, Das J, Marchant A, Goriely S
Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates
01/12/2022 - Cell Host Microbe
Zohar T, Hsiao J, Mehta N, Das J, [...], Espeseth A, Lauffenburger D, Bett A, Alter G
People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden
12/21/2021 - Cell Reports Medicine
Cillo A, Somasundaram A, Shan F, Cardello C, [...], Singh H, Morris A, Bruno T, Vignali D
Delayed fractional dosing with RTS, S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6-and Pf16-specific antibodies
11/12/2021 - Med
Das J*, Fallon J*, Yu T*, Michell A, [...], Lauffenburger D A, Jongert E, Wille-Reece U, Alter G
Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 Mutants
07/13/2021 - Frontiers in Physiology
Ningappa N, Adenuga N, Ngo K, Mohamed N, [...], Gittes G, Lo C, Subramaniam S, Sindhi R
Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection- A Proteomics Study
11/08/2020 - The Journal Of American Society of Nephrology
Clotet-Freixas S, McEvoy C, Batruch I, Pastrello C, [...], Jurisica I, Chruscinski A, John R, Konvalinka A
Mining for humoral correlates of HIV control and latent reservoir size
10/13/2020 - PLOS Pathogens
Das J*, Devadhasan A, Linde C, Broge T, [...], Julg B, Deeks S, Lauffenburger D, Alter G
Glucosylation by the Legionella effector SetA promotes the nuclear localization of the transcription factor TFEB
07/24/2020 - iScience
Beck W, Kim D, Das J, Yu H, Marcus B, Smolka M, Mao Y
Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination
07/22/2020 - Science Translational Medicine
Suscovich T*, Fallon J*, Das J*, Demas A*, [...], Bhatia S, Jongert E, Wilke-Reece U, Alter G
Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge
05/12/2020 - Cell Reports
Felber B, Lu Z, Hu Z, Valentin A, [...], Ferrari G, Ackerman M, Haynes B, Pavlakis G
Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells
03/20/2020 - PLoS Pathogens
Boucau J, Das J, Joshi N, Le Gall S
Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis
03/04/2020 - Journal of Hepatology
Weichselbaum L, Azouz A, Smolen K, Das J, [...], Trepo E, Libert F, Gustot T, Goriely S
Antibody Fc-glycosylation discriminates latent and active tuberculosis
02/20/2020 - The Journal of Infectious Diseases
Lu L*, Das J*, Grace P, Fortune S, Restrepo B, Alter G
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
09/12/2019 - Nature Communications
Fragoza R*, Das J*, Wierbowski S, Liang J, [...], Keinan A, Schimenti J, Clark A, Yu H
Antibiotics-driven gut microbiome perturbation alters immunity to vaccine in humans
09/05/2019 - Cell
Hagan T, Cortese M, Rouphael N, Boudreau C, [...], Alter G, Khurana S, Golding H, Pulendran B
Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys
08/15/2019 - JCI Insight
Natarajan N, Vujic A, Das J, Wang A, [...], Vaughan K, Colman R, Mattison J, Lee R
Fc glycan-mediated regulation of placental antibody transfer
07/27/2019 - Cell
Jennewein M, Goldfarb I, Dolatshahi S, Cosgrove C, [...], Lauffenburger D, Kim A, Riley L, Alter G
Genetic polymorphisms in the open reading frame of the CCR5 gene from HIV-1 seronegative and seropositive individuals from national capital regions of India
05/20/2019 - Scientific Reports
Ronsard L, Sood V, Yousif A, Ramesh J, [...], Sridharan S, Dorschel A, Ramachandran V, Banerjea A
Latent model-based clustering for biological discovery
04/26/2019 - iScience
Bin X, Royer M, Bunea F, Wegkamp M, Das J^
Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection related hospitalization in HIV-exposed uninfected infants
09/12/2018 - Clinical Infectious Diseases
Goetghebuer T*, Smolen K*, Adler C*, Das J*, [...], Lauffenburger DA, Alter G, Levy J, Marchant A
Analysis of Complement mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses and protection from infection in Rhesus macaques
09/12/2018 - Journal of Virology
Miller-Novak L, Das J, Musich T, Demberg T, [...], Tuero I, Ackerman M, Alter G, Robert-Guroff M
Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV
09/03/2018 - Nature Medicine
Ackerman M, Das J, Pittala S, Broge T, [...], Lauffenburger D, Bailey-Kellogg C, Roederer M, Alter G
A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus
08/08/2018 - Cell Host Microbe
Gunn B, Yu W, Karim M, Brannan J, [...], Andersen K, Dye J, Saphire E, Alter G
Control of heterologous SIVsmE660 infection by DNA and protein co-immunization regimens combined with different Toll-like receptor-4 (TLR-4) based adjuvants in macaques
07/17/2018 - Journal of Virology
Singh S, Ramirez-Salazar E, Doueiri R, Valentin A, [...], Venzon D, Hirsch V, Pavlakis G, Felber B
A multi-landing pad DNA integration platform for mammalian cell engineering
04/02/2018 - Nucleic Acids Research
Gaidukov L, Wroblewska L, Teague B, Nelson T, [...], Summers N, Lu T, Zhang L, Weiss R
The transcription factors Runx3, T-bet and ThPOK co-regulate acquisition of cytotoxic function by human Th1 lymphocytes
02/28/2018 - eLife
Serroukh Y, Gu-Trantien C, Hooshiar Kashani B, Defrance M, [...], Dalod M, Fuks F, Goriely S, Marchant A
Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous 4 controllers from chronic progressors
02/20/2018 - AIDS
Sadanand S*, Das J*, Chung A*, Schoen M, [...], Little S, Lauffenburger D, Richman D, Alter G
Mutation3D-cancer gene prediction through atomic clustering of coding variants in the structural proteome
02/03/2016 - Human Mutation
Meyer M, Lapcevic R, Romero A, Yoon M, [...], Stenson P, Cooper D, Paccanaro A, Yu H
A proteome-wide fission yeast interactome reveals network evolution principles from yeasts to human
01/14/2016 - Cell
Vo T*, Das J*, Meyer M*, Cordero N, [...], Roth F, Pleiss J, Xia Y, Yu H
Studying autism in context
11/25/2015 - Cell Systems
Das J*, Meyer M*, Yu H
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication
11/25/2015 - Molecular Cell
de Oliviera F, Kim D, Cussiol J, Das J, [...], Doerfler L, Schmidt K, Yu H, Smolka M
ENCAPP-elastic-net-based prognosis prediction and biomarker discovery for human cancers
03/16/2015 - BMC Genomics
Das J*, Gayvert K*, Bunea F, Wegkamp M, Yu H
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations
12/11/2014 - PLoS Genetics
Wei X*, Das J*, Fragoza R*, Liang J*, [...], Cooper D, Lipkin S, Smolka M, Yu H
Predicting cancer prognosis using functional genomics datasets
11/02/2014 - Cancer Informatics
Das J*, Gayvert K*, Yu H
Exploring mechanisms of human disease through structurally-resolved protein interactome networks
03/05/2014 - Molecular BioSystems
Das J*, Fragoza R*, Lee H, Cordero N, [...], Meyer M, Vo T, Wang X, Yu H
Elucidating common structural features of human pathogenic variations using large-scale atomic-resolution protein networks
01/01/2014 - Human Mutation
Das J, Lee H, Sagar A, Fragoza R, [...], Mort M, Stenson P, Cooper D, Yu H
Dissecting disease inheritance modes in a 3D protein network challenges the guilt-by-association principle
07/11/2013 - American Journal of Human Genetics
Guo Y, Wei X, Das J, Grimson A, Lipkin S, Clark A, Yu H
INstruct - a database of high-quality 3D structurally resolved protein interactome networks
06/11/2013 - Bioinformatics
Meyer M*, Das J*, Wang X*, Yu H
Integrative annotation of variants from 1,092 humans- application to cancer genomics
05/21/2013 - Science
Khurana E, Fu Y, Colonna V, Mu X, [...], Yu H, Rubin M, Tyler-Smith C, Gerstein M
Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways
05/21/2013 - Science Signaling
Das J*, Vo T*, Wei X, Mellor J, [...], Lipkin S, Yoshida M, Roth F, Yu H
HINT:High quality interactomes and their applications in understanding human disease
07/30/2012 - BMC Systems Biology
Das J*, Yu H
Genome-scale analysis of interaction dynamics reveals organization of biological networks
07/14/2012 - Bioinformatics
Das J*, Mohammed J*, Yu H
Three-dimensional reconstruction of protein networks provides insight into human genetic disease
01/15/2012 - Nature Biotechnology
Wang X*, Wei X*, Thijssen B*, Das J*, Lipkin S, Yu H