Published 'Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD' in 'The Journal of Clinical Investigation Insight'

Jishnu Das

Contributed to 'Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen' in 'Nature Immunology'

Jishnu Das

Contributed to 'High-dimensional profiling of immune responses to kidney transplant reveals heterogeneous T helper 1 and B cell effectors associated with rejection' in 'American Journal of Transplantation'

Jishnu Das

Contributed to 'Tim-3 Is Required for Regulatory T Cell?Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection' in 'Journal of Immunology'

Jishnu Das

Published 'Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis' in 'Science Translational Medicine'

Jishnu Das

Contributed to 'Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells' in 'Journal of Immunology'

Jishnu Das

Contributed to 'Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis' in 'Nature Communications'

Jishnu Das

Contributed to 'The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis' in 'Journal of Experimental Medicine'

Jishnu Das

Contributed to 'Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics' in 'PLoS Computational Biology'

Jishnu Das

Contributed to 'Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery: Impact of Aging and Comparison with Traumatic Injury Response' in 'Journal of the American College of Surgeons'

Jishnu Das

Contributed to 'Temporal dynamics and genomic programming of plasma cell fates' in 'Nature Immunology'

Jishnu Das

Jishnu presented our work at Senior Vice Chancellor?s Research Seminar Series 2024 on, 'From Bench to Bedside via Bytes: Using Machine Learning to Study the Immune System'

Jishnu Das

Jishnu gave an invited talk at Emory University ? Seminar 2024 on, 'Using machine learning and network systems approaches to uncover genetic and molecular determinants of immunological disorders'

Jishnu Das

NIAID U01 Flu Systems Vaccinology R01 (Role: MPI, PIs: Singh, Alcorn, Das)' funded. This grant focuses on developing advanced vaccination strategies for influenza.

Jishnu Das

Jishnu presented our work at 'Systems and Engineering Immunology Keystone 2024' on, 'Sliding Window Interaction Grammar (SWING) - a Generalized Interaction Language Model for Decoding Biological Interactions'

Jishnu Das

Published 'Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data' in 'Nature Computational Science'

Jishnu Das

Published 'SLIDE: Significant Latent factor Interaction Discovery and Exploration across biological domains' in 'Nature Methods'

Jishnu Das

Jishnu gave an invited talk at Pitt HuGen ? Seminar 2024 on, 'Using machine learning and network systems approaches to uncover genetic and molecular determinants of immunological disorders'

Jishnu Das

Swapnil Keshari received and award from NCWIT for mentoring high school student

Swapnil Keshari

Published 'From bench to bedside via bytes: multi-omic immunoprofiling and integration using machine learning and network approaches' in 'Human Vaccines and Immunotherapeutics'

Jishnu Das

Contributed to 'PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition' in 'Cell Reports Medicine'

Jishnu Das

Contributed to 'SARS-CoV2 mRNA vaccines induce greater complement activation and decreased viremia and Nef antibodies in men with HIV-1' in 'The Journal of Infectious Diseases'

Jishnu Das

Jishnu gave an invited talk at BMES 2023 on, 'Cell-type-specific biomarkers of systemic sclerosis disease severity capture cell-intrinsic and cell-extrinsic circuits'

Jishnu Das

Jishnu gave an invited talk at BMES 2023 on, 'Elucidating humoral profiles associated with Schistosomiasis pathogenesis using interpretable machine learning'

Jishnu Das

Jishnu gave an invited talk at BMES 2023 on, 'Significant latent factor interaction discovery and exploration across biological domains'

Jishnu Das

Published 'Cell Type-Specific Biomarkers of Systemic Sclerosis Disease Severity Capture Cell-Intrinsic and Cell-Extrinsic Circuits' in 'Arthritis & Rheumatology'

Jishnu Das

Contributed to 'Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A' in 'The Journal of Experimental Medicine'

Jishnu Das

NHLBI R01 Grant for Adenine Nucleotide Translocase in COPD (Role: Co-I)' funded. This grant supports research into the mechanisms of adenine nucleotide translocase in chronic obstructive pulmonary disease.

Jishnu Das

Contributed to 'The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells' in 'Immunity'

Jishnu Das

Published 'Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19' in 'Cell Reports'

Jishnu Das

NIGMS R35 (Role: Co-I, PI: Billiar)' funded. This grant is aimed at investigating molecular mechanisms in biomedical research.

Jishnu Das

Jishnu gave an invited talk at FASEB Autoimmunity 2023 on, 'Multi-dimensional integration of protein interactomes with genomic and molecular data discover distinct RA endotypes'

Jishnu Das

Contributed to 'Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates' in 'Cell Reports'

Jishnu Das

Jishnu gave an invited talk at Cold Spring Harbor Laboratory Systems Immunology Meeting 2023 on, 'Multi-dimensional integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes'

Jishnu Das

Jishnu gave an invited talk at Cold Spring Harbor Laboratory Systems Immunology Meeting 2023 on, 'Uncovering immunomodulatory molecular phenotypes in infectious disease using networks'

Jishnu Das

Contributed to 'High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma' in 'The Journal of Trauma and Acute Care Surgery'

Jishnu Das

NHLBI R35 (Role: Co-I, PI: A.Ray)' funded. This grant supports cardiovascular research to understand heart diseases.

Jishnu Das

NCI R01 on hypoxia in T cell differentiation in cancer (Role: Co-I, PI: Billiar)' funded. This grant focuses on the role of hypoxia in the differentiation of T cells within the tumor microenvironment.

Jishnu Das

Published 'Determining asthma endotypes and outcomes- Complementing existing clinical practice with modern machine learning' in 'Cell Reports Medicine'

Jishnu Das

Systemic Sclerosis Center for Research and Translation (Role: Co-I)' funded. This grant is for research into systemic sclerosis and developing translation methods.

Jishnu Das

U01 Grant for cell signaling circuits in ocular disorders (Role: Co-I)' funded. This grant focuses on understanding cell signaling in eye diseases.

Jishnu Das

Jishnu gave an invited talk at BMES 2022 on, 'Essential Regression: A generalizable framework for inferring causal latent factors from multi-omic datasets'

Jishnu Das

Jishnu gave an invited talk at BMES 2022 on, 'Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19'

Jishnu Das

Jishnu gave an invited talk at BMES 2022 on, 'A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation'

Jishnu Das

Jishnu gave an invited talk at the Banff-CST Joint Transplant and Pathology Summit titled 'Machine learning in clinical decision making in transplant biology'

Jishnu Das

Published 'A supervised take on dimensionality reduction via hybrid subset selection' in 'Patterns'

Jishnu Das

Contributed to 'Functional reprogramming of monocytes in acute and convalescent severe COVID-19 patients' in 'JCI Insight'

Jishnu Das

RO1 on antibody responses in COVID-19 (Role: Co-I)' funded. This grant supports research into the immune response to COVID-19, particularly antibody production.

Jishnu Das

Jishnu gave a talk at International Workshop on Scleroderma 2022 in Boston.

Jishnu Das

Our work covered in Pittsburgh's Action 4 News '4 Your Health: Studying COVID-19 antibody patterns'

Jishnu Das

Scleroderma CDMRP Award (Role: Co-I)' funded. This grant supports research into the pathogenesis and treatment of scleroderma.

Jishnu Das

Systems Immunology Core (funded by NIAMS P50) (Role: Co-Director)' funded. This grant focuses on the establishment and development of a Systems Immunology Core.

Jishnu Das

Jishnu gave an invited talk at ISMB 2022 on the topic 'A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation'

Jishnu Das

Published 'Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30 Day Survival in Trauma Patients' in 'Metabolites'

Jishnu Das

Published 'High Dimensional Multi-omics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients with TBI' in 'Annals of Surgery'

Jishnu Das

Published 'Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associated with favorable outcomes in severe COVID-19' in 'Cell Press'

Jishnu Das

Contributed to 'Autoreactive antibodies play a role in acute kidney injury and dialysis requirement in patients with COVID-19' in 'Kidney International'

Jishnu Das

Contributed to 'Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity' in 'Cell Host and Microbe'

Jishnu Das

NIAID Flu Systems Vaccinology R01 (Role: MPI, PIs: Alcorn, Singh, Zimmerman)' funded. This grant supports the development of novel flu vaccines using systems vaccinology approaches.

Jishnu Das

Pitt-Case Western CFAR application funded by NIAID Rustbelt (Role: Co-I)' funded. This grant supports collaborative AIDS research between Pitt and Case Western.

Jishnu Das

Published 'Integrating bulk RNA-seq data with protein networks can uncover signatures underlying rejection in pediatric liver transplantation' in 'Cell Reports Medicine'

Jishnu Das

CIHR grant (Role: Co-I, PI: Konvalinka)' funded. This grant supports Canadian Institutes of Health Research in biomedical studies.

Jishnu Das

Published 'A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation' in 'Cell Reports Medicine'

Jishnu Das

Published 'Essential Regression: A generalizable framework for inferring causal latent factors from multi-omic datasets' in 'Patterns'

Jishnu Das

DoD grant for scleroderma disease severity (Role: Co-I, PIs: Lafyatis and Singh)' funded. This grant supports research into the severity and mechanisms of scleroderma.

Jishnu Das

Scleroderma Program Idea Development Award (Role: Co-I, PI: Lafyatis)' funded. This grant aims at developing new ideas for scleroderma research.

Jishnu Das

NIAID R01 for COVID-19 vaccine responses in HIV (Role: Co-I, PIs: Rinaldo and Mailliard)' funded. This grant focuses on the response to COVID-19 vaccines in HIV-positive individuals.

Jishnu Das

5-year NHGRI U01 1U01HG012041-01 (Role: MPI, PIs: Singh, Sahni)' funded. This grant supports genomic research over a five-year period.

Jishnu Das

5-year NIAID New Innovator DP2 Award 1DP2AI164325-01 (Role: PI)' funded. This grant supports innovative research in immunology.

Jishnu Das

Contributed to 'Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates' in 'Cell Host and Microbe'

Jishnu Das

Contributed to 'Mechanisms of impaired lung development and ciliation in Mannosidase-1-alpha-2 (Man1a2) mutants' in 'Frontiers in Physiology'

Jishnu Das

NIDDK dkNET New Investigator Pilot Program in Bioinformatics (Role: Co-I, PI: Joglekar)' funded. This grant supports new investigators in bioinformatics and kidney disease research.

Jishnu Das

Department of Defense Idea Development Award (Role: Co-I, PI: Lafyatis)' funded. This grant aims to develop new research ideas for the Department of Defense.

Jishnu Das

Jishnu gave a talk at the 2021 Cold Spring Harbor Systems Immunology Meeting on 'CausER ? a general approach to uncover latent causal factors from multi-omic datasets'

Jishnu Das

Jishnu gave a talk at the 2021 Cold Spring Harbor Networks Meeting on 'Network-based multi-omic integration unveils novel molecular programs underlying T follicular helper cell differentiation in immunological disorders'

Jishnu Das

Jishnu gave an invited talk at the University of Iowa College of Medicine Seminar Series 2021 on 'Using machine learning and network systems approaches to uncover molecular phenotypes underlying pathophysiology of immune disorders'

Jishnu Das

Published 'Mining for humoral correlates of HIV control and latent reservoir size' in 'PLoS Pathogens'

Jishnu Das

Contributed to 'Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study' in 'The Journal of the American Society of Nephrology'

Jishnu Das

Collaborative Research Agreement with University of Brussels Center for Research In Immunology (Role: PI)' funded. This grant supports collaborative immunology research with the University of Brussels.

Jishnu Das

Contributed to 'Glucosylation by the Legionella effector SetA promotes the nuclear localization of the transcription factor TFEB' in 'iScience'

Jishnu Das

Published 'Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination' in 'Science Translational Medicine'

Jishnu Das