Jishnu Das
Jishnu Das

Machine Learning, Networks, Immunology, Coffee and Music

Leveraging diverse expertise to pioneer method development and apply practical solutions to diverse biological challenges!

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Top Pick's

Selected Work

SLIDE- Significant Latent factor Interaction Discovery and Exploration across biological domains

SLIDE- Significant Latent factor Interaction Discovery and Exploration across biological domains

Nature Methods 2024

Machine_Learning
From bench to bedside via bytes- multi-omic immunoprofiling and integration using machine learning and network approaches

From bench to bedside via bytes- multi-omic immunoprofiling and integration using machine learning and network approaches

Human Vaccines & Immunotherapeutics 2023

Protein_Networks Machine_Learning
High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI

High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI

Annals of Surgery 2022

Protein_Networks
Essential Regression- A generalizable framework for inferring causal latent factors from multi-omic datasets

Essential Regression- A generalizable framework for inferring causal latent factors from multi-omic datasets

Patterns 2022

Machine_Learning
A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation

A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation

Cell Reports Medicine 2022

Gene_Regulatory_Networks Machine_Learning
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Nature Communications 2019

Protein_Networks
Antibiotics-driven gut microbiome perturbation alters immunity to vaccine in humans

Antibiotics-driven gut microbiome perturbation alters immunity to vaccine in humans

Cell 2019

Antibodyomics
Genetic polymorphisms in the open reading frame of the CCR5 gene from HIV-1 seronegative and seropositive individuals from national capital regions of India

Genetic polymorphisms in the open reading frame of the CCR5 gene from HIV-1 seronegative and seropositive individuals from national capital regions of India

Scientific Reports 2019

Gene_Regulatory_Networks
Latent model-based clustering for biological discovery

Latent model-based clustering for biological discovery

iScience 2019

Machine_Learning
Daryl Mercer

Hi there ! 👋 Welcome to Jishnu's Systems Immunology Lab.

As a computational systems immunology lab, our research focuses on the development and use of novel systems approaches to analyze high-dimensional immunological datasets, and elucidate molecular mechanisms of immunological disorders. We are currently working on using network systems and functional genomic approaches to perform multi-scale integration of genomic and epigenomic datasets with biological networks to identify molecular phenotypes underlying these immunological disorders. We also use statistical and machine-learning techniques to integrate multi-omic datasets (genomic, transcriptomic, proteomic, metabolomic and antibody-omic) and elucidate molecular mechanisms of immune regulation and dysregulation.

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