A community of interest bringing together innovative computational approaches to tackle the unique challenges of immune system analysis — from repertoire profiling to neoantigen prediction.
Join our SlackJuly 12–16, 2026 · Washington, DC
The 34th Intelligent Systems for Molecular Biology conference returns to Washington, DC — the very city where ISCB and ISMB began in 1993. This landmark meeting celebrates over 30 years of advancing computational biology, hosted at the Washington Hilton with a hybrid virtual option via ISCB's Nucleus platform.
The CSI COSI track will be a featured part of the program, bringing computational immunology front and center at the world's largest bioinformatics conference. 600+ scientific talks, tutorials, networking events, and more await.
Learn More & RegisterWho we are
The Computational Systems Immunology (CSI) COSI provides a platform for discussing innovative computational methods to tackle the challenges specific to immune system analysis. The COSI fosters discussions that drive both fundamental research and translational discoveries in immunology, ensuring computational approaches keep pace with the evolving landscape of immune system studies.
CSI is organized as a full-day track within the annual ISMB conference, featuring keynote lectures, invited talks, trainee presentations, and short talks selected from submitted abstracts.
Topics of interest
2025 Inaugural Program
2025 marked the first year of Computational and Systems Immunology COSI. The day-long program opened with a packed room for the keynote by Dr. Julio Saez-Rodriguez on using multiomic and spatial data alongside biological knowledge to model gene regulatory and signalling networks.
This was followed by a talk from Dr. Robert F. Murphy (founder and former chair, Computational Biology Department, Carnegie Mellon) on a vision-transformer-based cell annotation method for highly multiplexed tissue images. The morning session also featured talks on protein expression imputation from spatial transcriptomics data and a spatial and single-cell study of the human thymus.
Keynote on multiomic & spatial regulatory network modeling · Vision transformer cell annotation for multiplexed tissue images · Protein expression imputation from spatial transcriptomics · Human thymus aging and dysfunction.
Transcriptional regulatory code of immune cells using an expanded DNA motif lexicon · Transcriptional regulators of Tfh differentiation · Double-negative B cells in cancer · Heavy/light chain pairing prediction.
Phylogeny-informed B cell epitope prediction · Improved TCR–epitope binding models · Neoantigen immunogenicity prediction in cancer · SHISMA: cell-type-specific regulatory pattern inference.
The day concluded with five-minute lightning talks selected from submitted abstracts, showcasing emerging work from trainees and early-career researchers across systems immunology.
ISMB 2026 · CSI COSI
Leadership
Our Commitment
We value diversity of backgrounds, expertise, and opinion across our organizing committee, steering committee, keynote speakers, and invited speakers. Our goal is to provide a platform for information exchange and to stimulate collaborations across a diverse set of attendees that is representative of the general ISMB audience.
Going forward, our keynote speaker list will feature more female scientists and researchers from outside North America, and we will ensure at least one early-career faculty member doing high-impact work is represented. We will actively seek out speakers from underrepresented groups, including women, racial and ethnic minorities, and individuals from diverse geographic regions, as well as voices from industry and non-traditional research settings.
Prioritizing female scientists, researchers outside North America, and early-career faculty for keynote and invited talks.
Deliberately balancing senior and junior researchers when selecting invited talks, and highlighting trainee contributions through short talks.
Actively including voices from industry and non-traditional research settings to reflect the full spectrum of the Systems Immunology field.
Stay Connected
Connect with researchers and practitioners in Computational Systems Immunology. Join our Slack workspace to stay up to date on the COSI, upcoming events, and community discussions.
Join on SlackAlso part of ISCB COSIs · ISMB Conference